ChloroquineV1, an2020, Analysis, bibRecord, 000160

Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites

Identifieur interne : 000160 ( an2020/Analysis ); précédent : 000159; suivant : 000161

Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites

Auteurs : Nanika Coetzee ; Hilde Von Grüning ; Daniel Opperman ; Mariette Van Der Watt ; Janette Reader ; Lyn-Marié Birkholtz

Source :

Scientific Reports [ 2045-2322 ] ; 2020.

RBID : PMC:7012883

Abstract

The epigenome of the malaria parasite, Plasmodium falciparum, is associated with regulation of various essential processes in the parasite including control of proliferation during asexual development as well as control of sexual differentiation. The unusual nature of the epigenome has prompted investigations into the potential to target epigenetic modulators with novel chemotypes. Here, we explored the diversity within a library of 95 compounds, active against various epigenetic modifiers in cancerous cells, for activity against multiple stages of P. falciparum development. We show that P. falciparum is differentially susceptible to epigenetic perturbation during both asexual and sexual development, with early stage gametocytes particularly sensitive to epi-drugs targeting both histone and non-histone epigenetic modifiers. Moreover, 5 compounds targeting histone acetylation and methylation show potent multistage activity against asexual parasites, early and late stage gametocytes, with transmission-blocking potential. Overall, these results warrant further examination of the potential antimalarial properties of these hit compounds.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012883

DOI: 10.1038/s41598-020-59298-4
PubMed: 32047203
PubMed Central: 7012883

Affiliations:

Links to Exploration step

PMC:7012883

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Epigenetic inhibitors target multiple stages of <italic>Plasmodium falciparum</italic>
 parasites</title>
<author><name sortKey="Coetzee, Nanika" sort="Coetzee, Nanika" uniqKey="Coetzee N" first="Nanika" last="Coetzee">Nanika Coetzee</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Von Gruning, Hilde" sort="Von Gruning, Hilde" uniqKey="Von Gruning H" first="Hilde" last="Von Grüning">Hilde Von Grüning</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Opperman, Daniel" sort="Opperman, Daniel" uniqKey="Opperman D" first="Daniel" last="Opperman">Daniel Opperman</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Der Watt, Mariette" sort="Van Der Watt, Mariette" uniqKey="Van Der Watt M" first="Mariette" last="Van Der Watt">Mariette Van Der Watt</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Reader, Janette" sort="Reader, Janette" uniqKey="Reader J" first="Janette" last="Reader">Janette Reader</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Birkholtz, Lyn Marie" sort="Birkholtz, Lyn Marie" uniqKey="Birkholtz L" first="Lyn-Marié" last="Birkholtz">Lyn-Marié Birkholtz</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32047203</idno>
<idno type="pmc">7012883</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012883</idno>
<idno type="RBID">PMC:7012883</idno>
<idno type="doi">10.1038/s41598-020-59298-4</idno>
<date when="2020">2020</date>
<idno type="wicri:Area/Pmc/Corpus">000204</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000204</idno>
<idno type="wicri:Area/Pmc/Curation">000204</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000204</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000150</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000150</idno>
<idno type="wicri:Area/Ncbi/Merge">000F23</idno>
<idno type="wicri:Area/Ncbi/Curation">000F23</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000F23</idno>
<idno type="wicri:Area/Main/Merge">000160</idno>
<idno type="wicri:Area/Main/Curation">000160</idno>
<idno type="wicri:Area/Main/Exploration">000160</idno>
<idno type="wicri:Area/an2020/Extraction">000160</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Epigenetic inhibitors target multiple stages of <italic>Plasmodium falciparum</italic>
 parasites</title>
<author><name sortKey="Coetzee, Nanika" sort="Coetzee, Nanika" uniqKey="Coetzee N" first="Nanika" last="Coetzee">Nanika Coetzee</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Von Gruning, Hilde" sort="Von Gruning, Hilde" uniqKey="Von Gruning H" first="Hilde" last="Von Grüning">Hilde Von Grüning</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Opperman, Daniel" sort="Opperman, Daniel" uniqKey="Opperman D" first="Daniel" last="Opperman">Daniel Opperman</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Der Watt, Mariette" sort="Van Der Watt, Mariette" uniqKey="Van Der Watt M" first="Mariette" last="Van Der Watt">Mariette Van Der Watt</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Reader, Janette" sort="Reader, Janette" uniqKey="Reader J" first="Janette" last="Reader">Janette Reader</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Birkholtz, Lyn Marie" sort="Birkholtz, Lyn Marie" uniqKey="Birkholtz L" first="Lyn-Marié" last="Birkholtz">Lyn-Marié Birkholtz</name>
<affiliation><nlm:aff id="Aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Scientific Reports</title>
<idno type="eISSN">2045-2322</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="Par1">The epigenome of the malaria parasite, <italic>Plasmodium falciparum</italic>
, is associated with regulation of various essential processes in the parasite including control of proliferation during asexual development as well as control of sexual differentiation. The unusual nature of the epigenome has prompted investigations into the potential to target epigenetic modulators with novel chemotypes. Here, we explored the diversity within a library of 95 compounds, active against various epigenetic modifiers in cancerous cells, for activity against multiple stages of <italic>P. falciparum</italic>
 development. We show that <italic>P. falciparum</italic>
 is differentially susceptible to epigenetic perturbation during both asexual and sexual development, with early stage gametocytes particularly sensitive to epi-drugs targeting both histone and non-histone epigenetic modifiers. Moreover, 5 compounds targeting histone acetylation and methylation show potent multistage activity against asexual parasites, early and late stage gametocytes, with transmission-blocking potential. Overall, these results warrant further examination of the potential antimalarial properties of these hit compounds.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Miller, Lh" uniqKey="Miller L">LH Miller</name>
</author>
<author><name sortKey="Ackerman, Hc" uniqKey="Ackerman H">HC Ackerman</name>
</author>
<author><name sortKey="Su, Xz" uniqKey="Su X">XZ Su</name>
</author>
<author><name sortKey="Wellems, Te" uniqKey="Wellems T">TE Wellems</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burrows, Jn" uniqKey="Burrows J">JN Burrows</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Phillips, Ma" uniqKey="Phillips M">MA Phillips</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Audia, Je" uniqKey="Audia J">JE Audia</name>
</author>
<author><name sortKey="Campbell, Rm" uniqKey="Campbell R">RM Campbell</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Dhanak, D" uniqKey="Dhanak D">D Dhanak</name>
</author>
<author><name sortKey="Jackson, P" uniqKey="Jackson P">P Jackson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coetzee, N" uniqKey="Coetzee N">N Coetzee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abel, Steven" uniqKey="Abel S">Steven Abel</name>
</author>
<author><name sortKey="Le Roch, Karine G" uniqKey="Le Roch K">Karine G Le Roch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, Ap" uniqKey="Gupta A">AP Gupta</name>
</author>
<author><name sortKey="Bozdech, Z" uniqKey="Bozdech Z">Z Bozdech</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duraisingh, Mt" uniqKey="Duraisingh M">MT Duraisingh</name>
</author>
<author><name sortKey="Skillman, Km" uniqKey="Skillman K">KM Skillman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cortes, Alfred" uniqKey="Cortes A">Alfred Cortés</name>
</author>
<author><name sortKey="Deitsch, Kirk W" uniqKey="Deitsch K">Kirk W. Deitsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salcedo Amaya, Am" uniqKey="Salcedo Amaya A">AM Salcedo-Amaya</name>
</author>
<author><name sortKey="Hoeijmakers, Wa" uniqKey="Hoeijmakers W">WA Hoeijmakers</name>
</author>
<author><name sortKey="Bartfai, R" uniqKey="Bartfai R">R Bartfai</name>
</author>
<author><name sortKey="Stunnenberg, Hg" uniqKey="Stunnenberg H">HG Stunnenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trenholme, K" uniqKey="Trenholme K">K Trenholme</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouchut, A" uniqKey="Bouchut A">A Bouchut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Malmquist, Na" uniqKey="Malmquist N">NA Malmquist</name>
</author>
<author><name sortKey="Moss, Ta" uniqKey="Moss T">TA Moss</name>
</author>
<author><name sortKey="Mecheri, S" uniqKey="Mecheri S">S Mecheri</name>
</author>
<author><name sortKey="Scherf, A" uniqKey="Scherf A">A Scherf</name>
</author>
<author><name sortKey="Fuchter, Mj" uniqKey="Fuchter M">MJ Fuchter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Malmquist, Na" uniqKey="Malmquist N">NA Malmquist</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Sundriyal, S" uniqKey="Sundriyal S">S Sundriyal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prusty, D" uniqKey="Prusty D">D Prusty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andrews, Kt" uniqKey="Andrews K">KT Andrews</name>
</author>
<author><name sortKey="Tran, Tn" uniqKey="Tran T">TN Tran</name>
</author>
<author><name sortKey="Wheatley, Nc" uniqKey="Wheatley N">NC Wheatley</name>
</author>
<author><name sortKey="Fairlie, Dp" uniqKey="Fairlie D">DP Fairlie</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Chaal, Bk" uniqKey="Chaal B">BK Chaal</name>
</author>
<author><name sortKey="Gupta, Ap" uniqKey="Gupta A">AP Gupta</name>
</author>
<author><name sortKey="Wastuwidyaningtyas, Bd" uniqKey="Wastuwidyaningtyas B">BD Wastuwidyaningtyas</name>
</author>
<author><name sortKey="Luah, Yh" uniqKey="Luah Y">YH Luah</name>
</author>
<author><name sortKey="Bozdech, Z" uniqKey="Bozdech Z">Z Bozdech</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Engel, Ja" uniqKey="Engel J">JA Engel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, Ap" uniqKey="Gupta A">AP Gupta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ngwa, Cj" uniqKey="Ngwa C">CJ Ngwa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trenholme, K" uniqKey="Trenholme K">K Trenholme</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marfurt, J" uniqKey="Marfurt J">J Marfurt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ontoria, Jm" uniqKey="Ontoria J">JM Ontoria</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hansen, Fk" uniqKey="Hansen F">FK Hansen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shen, S" uniqKey="Shen S">S Shen</name>
</author>
<author><name sortKey="Kozikowski, Ap" uniqKey="Kozikowski A">AP Kozikowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Watt, Me" uniqKey="Van Der Watt M">ME van der Watt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ngwa, Che Julius" uniqKey="Ngwa C">Che Julius Ngwa</name>
</author>
<author><name sortKey="Kiesow, Meike Jutta" uniqKey="Kiesow M">Meike Jutta Kiesow</name>
</author>
<author><name sortKey="Orchard, Lindsey Marie" uniqKey="Orchard L">Lindsey Marie Orchard</name>
</author>
<author><name sortKey="Farrukh, Afia" uniqKey="Farrukh A">Afia Farrukh</name>
</author>
<author><name sortKey="Llinas, Manuel" uniqKey="Llinas M">Manuel Llinás</name>
</author>
<author><name sortKey="Pradel, Gabriele" uniqKey="Pradel G">Gabriele Pradel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ukaegbu, Ue" uniqKey="Ukaegbu U">UE Ukaegbu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cui, L" uniqKey="Cui L">L Cui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duffy, Mf" uniqKey="Duffy M">MF Duffy</name>
</author>
<author><name sortKey="Selvarajah, Sa" uniqKey="Selvarajah S">SA Selvarajah</name>
</author>
<author><name sortKey="Josling, Ga" uniqKey="Josling G">GA Josling</name>
</author>
<author><name sortKey="Petter, M" uniqKey="Petter M">M Petter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Merrick, Cj" uniqKey="Merrick C">CJ Merrick</name>
</author>
<author><name sortKey="Duraisingh, Mt" uniqKey="Duraisingh M">MT Duraisingh</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Chua, Mj" uniqKey="Chua M">MJ Chua</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dow, Gs" uniqKey="Dow G">GS Dow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giannini, G" uniqKey="Giannini G">G Giannini</name>
</author>
<author><name sortKey="Battistuzzi, G" uniqKey="Battistuzzi G">G Battistuzzi</name>
</author>
<author><name sortKey="Vignola, D" uniqKey="Vignola D">D Vignola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sumanadasa, Sd" uniqKey="Sumanadasa S">SD Sumanadasa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Horrocks, P" uniqKey="Horrocks P">P Horrocks</name>
</author>
<author><name sortKey="Wong, E" uniqKey="Wong E">E Wong</name>
</author>
<author><name sortKey="Russell, K" uniqKey="Russell K">K Russell</name>
</author>
<author><name sortKey="Emes, Rd" uniqKey="Emes R">RD Emes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chaal, Bk" uniqKey="Chaal B">BK Chaal</name>
</author>
<author><name sortKey="Gupta, Ap" uniqKey="Gupta A">AP Gupta</name>
</author>
<author><name sortKey="Wastuwidyaningtyas, Bd" uniqKey="Wastuwidyaningtyas B">BD Wastuwidyaningtyas</name>
</author>
<author><name sortKey="Luah, Yh" uniqKey="Luah Y">YH Luah</name>
</author>
<author><name sortKey="Bozdech, Z" uniqKey="Bozdech Z">Z Bozdech</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hailu, Gs" uniqKey="Hailu G">GS Hailu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miranda, Tb" uniqKey="Miranda T">TB Miranda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, Ap" uniqKey="Gupta A">AP Gupta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karmodiya, K" uniqKey="Karmodiya K">K Karmodiya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoeijmakers, Wa" uniqKey="Hoeijmakers W">WA Hoeijmakers</name>
</author>
<author><name sortKey="Stunnenberg, Hg" uniqKey="Stunnenberg H">HG Stunnenberg</name>
</author>
<author><name sortKey="Bartfai, R" uniqKey="Bartfai R">R Bartfai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lai, Ys" uniqKey="Lai Y">YS Lai</name>
</author>
<author><name sortKey="Chen, Jy" uniqKey="Chen J">JY Chen</name>
</author>
<author><name sortKey="Tsai, Hj" uniqKey="Tsai H">HJ Tsai</name>
</author>
<author><name sortKey="Chen, Ty" uniqKey="Chen T">TY Chen</name>
</author>
<author><name sortKey="Hung, Wc" uniqKey="Hung W">WC Hung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greiner, D" uniqKey="Greiner D">D Greiner</name>
</author>
<author><name sortKey="Bonaldi, T" uniqKey="Bonaldi T">T Bonaldi</name>
</author>
<author><name sortKey="Eskeland, R" uniqKey="Eskeland R">R Eskeland</name>
</author>
<author><name sortKey="Roemer, E" uniqKey="Roemer E">E Roemer</name>
</author>
<author><name sortKey="Imhof, A" uniqKey="Imhof A">A Imhof</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eckschlager, Tomas" uniqKey="Eckschlager T">Tomas Eckschlager</name>
</author>
<author><name sortKey="Plch, Johana" uniqKey="Plch J">Johana Plch</name>
</author>
<author><name sortKey="Stiborova, Marie" uniqKey="Stiborova M">Marie Stiborova</name>
</author>
<author><name sortKey="Hrabeta, Jan" uniqKey="Hrabeta J">Jan Hrabeta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grozinger, Cm" uniqKey="Grozinger C">CM Grozinger</name>
</author>
<author><name sortKey="Chao, Ed" uniqKey="Chao E">ED Chao</name>
</author>
<author><name sortKey="Blackwell, He" uniqKey="Blackwell H">HE Blackwell</name>
</author>
<author><name sortKey="Moazed, D" uniqKey="Moazed D">D Moazed</name>
</author>
<author><name sortKey="Schreiber, Sl" uniqKey="Schreiber S">SL Schreiber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khochbin, S" uniqKey="Khochbin S">S Khochbin</name>
</author>
<author><name sortKey="Verdel, A" uniqKey="Verdel A">A Verdel</name>
</author>
<author><name sortKey="Lemercier, C" uniqKey="Lemercier C">C Lemercier</name>
</author>
<author><name sortKey="Seigneurin Berny, D" uniqKey="Seigneurin Berny D">D Seigneurin-Berny</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bernstein, Be" uniqKey="Bernstein B">BE Bernstein</name>
</author>
<author><name sortKey="Tong, Jk" uniqKey="Tong J">JK Tong</name>
</author>
<author><name sortKey="Schreiber, Sl" uniqKey="Schreiber S">SL Schreiber</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Peck, B" uniqKey="Peck B">B Peck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, J" uniqKey="Chang J">J Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finnin, Ms" uniqKey="Finnin M">MS Finnin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reader, J" uniqKey="Reader J">J Reader</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verlinden, Bk" uniqKey="Verlinden B">BK Verlinden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Lessandro, S" uniqKey="D Lessandro S">S D’Alessandro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moyo, P" uniqKey="Moyo P">P Moyo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ruecker, A" uniqKey="Ruecker A">A Ruecker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Biljon, Ra" uniqKey="Van Biljon R">RA van Biljon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirai, S" uniqKey="Hirai S">S Hirai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kikuchi, J" uniqKey="Kikuchi J">J Kikuchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takai, N" uniqKey="Takai N">N Takai</name>
</author>
<author><name sortKey="Narahara, H" uniqKey="Narahara H">H Narahara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zappasodi, R" uniqKey="Zappasodi R">R Zappasodi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Janaki Ramaiah, M" uniqKey="Janaki Ramaiah M">M Janaki Ramaiah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liao, X" uniqKey="Liao X">X Liao</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Birkholtz, Lyn Marie" sort="Birkholtz, Lyn Marie" uniqKey="Birkholtz L" first="Lyn-Marié" last="Birkholtz">Lyn-Marié Birkholtz</name>
<name sortKey="Coetzee, Nanika" sort="Coetzee, Nanika" uniqKey="Coetzee N" first="Nanika" last="Coetzee">Nanika Coetzee</name>
<name sortKey="Opperman, Daniel" sort="Opperman, Daniel" uniqKey="Opperman D" first="Daniel" last="Opperman">Daniel Opperman</name>
<name sortKey="Reader, Janette" sort="Reader, Janette" uniqKey="Reader J" first="Janette" last="Reader">Janette Reader</name>
<name sortKey="Van Der Watt, Mariette" sort="Van Der Watt, Mariette" uniqKey="Van Der Watt M" first="Mariette" last="Van Der Watt">Mariette Van Der Watt</name>
<name sortKey="Von Gruning, Hilde" sort="Von Gruning, Hilde" uniqKey="Von Gruning H" first="Hilde" last="Von Grüning">Hilde Von Grüning</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/an2020/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000160 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd -nk 000160 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    an2020
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:7012883
   |texte=   Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/an2020/Analysis/RBID.i   -Sk "pubmed:32047203" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites

Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.